Nuclear bodies contribute to non‐random organization of the human genome and nuclear function. Using a major prototypical nuclear body, the Cajal body, as an example, we suggest that these structures assemble at specific gene loci located across the genome as a result of high transcriptional activity. Subsequently, target genes are physically clustered in close proximity in Cajal body‐containing cells. However, Cajal bodies are observed in only a limited number of human cell types, including neuronal and cancer cells. Ultimately, Cajal body (...) depletion perturbs splicing kinetics by reducing target small nuclear RNA (snRNA) transcription and limiting the levels of spliceosomal snRNPs, including their modification and turnover following each round of RNA splicing. As such, Cajal bodies are capable of shaping the chromatin interaction landscape and the transcriptome by influencing spliceosome kinetics. Future studies should concentrate on characterizing the direct influence of Cajal bodies upon snRNA gene transcriptional dynamics.Also see the video abstract here. (shrink)

This paper investigates the difficulties of creating economic, social, and environmental values when operating as a hybrid venture. Drawing on hybrid organizing and sustainable business model research, it explores the implications of alternative forms of business model experimented with by farmer owned, fairtrade social enterprise Cafédirect. Responding to changes and challenges in the market and societal environment, Cafédirect has tried multiple business model innovations to deliver on all three forms of value capture, with differing levels of success. This longitudinal case (...) study, therefore, provides a contribution to our understanding of how business models enact hybrid mission, providing a platform for triple-bottom-line value capture. In doing so, we are able to expand on the normative understandings of integrating hybrid objectives, and the complications of multiple types of value capture. (shrink)

This article explores the extent to which consumers consider ethics in luxury goods consumption. In particular, it explores whether there is a significant difference between consumers’ propensity to consider ethics in luxury versus commodity purchase and whether consumers are ready to purchase ethical-luxury. Prior research in ethical consumption focuses on low value, commoditized product categories such as food, cosmetics and high street apparel. It is debatable if consumers follow similar ethical consumption patterns in luxury purchases. Findings indicate that consumers’ propensity (...) to consider ethics is significantly lower in luxury purchases when compared to commoditized purchases and explores some of the potential reasons for this reduced propensity to identify or act upon ethical issues in luxury consumption. (shrink)

This paper reports on a study of ethical decision-making in a fair trade company. This can be seen to be a crucial arena for investigation since fair trade firms not only have a specific ethical mission in terms of helping growers out of poverty, but they tend to be perceived as (and are often marketed on the basis of) having an "ethical" image. Eschewing a straightforward test of extant ethical decision models, we adopt Thompson''s proposal for a more contextualist understanding (...) rooted in ethnographic data. Our findings suggest that the fair trade mission of the firm is experienced as an over-riding ethical claim, which is often invoked to justify potentially ethically questionable decisions. Moreover, decision precedents emerge which can mean that the decision process is bypassed or hurried through. Finally we provide evidence that the significance of these precedents, and indeed, even moral intensity itself, could be actively shaped and constructed by organization members to support different, even shifting, conceptions of what is a morally acceptable decision for a fair trade company to make. (shrink)

This is a case study investigating the growth of fair trade pioneer, Cafédirect. We explore the growth of the company and develop strategic insights on how Cafédirect has attained its prominent position in the UK mainstream coffee industry based on its ethical positioning. We explore the marketing, networks and communications channels of the brand which have led to rapid growth from niche player to a mainstream brand. However, the company is experiencing a slow down in its meteoric rise and we (...) question whether it is possible for the company to regain its former momentum with its current marketing strategy. (shrink)

Employee buy-in is a key factor in ensuring small- and medium-size enterprise (SME) engagement with corporate social responsibility (CSR). In this exploratory study, we use participant observation and semi-structured interviews to investigate the way in which three fair trade SMEs utilise human resource management (and selection and socialisation in particular) to create employee engagement in a strong triple bottomline philosophy, while simultaneously coping with resource and size constraints. The conclusions suggest that there is a strong desire for, but tradeoff within (...) these companies between selection of individuals who already identify with the triple bottomline philosophy and individuals with experience and capability to deal with mainstream brand management – two critical employee attributes that appear to be rarely found together. The more important the business experience to the organisation, the more effort the organisation must expend in formalising their socialisation programmes to ensure employee engagement. A key method in doing this is increasing employee knowledge of, and affection for, the target beneficiaries of the CSR programme (increased moral intensity). (shrink)

Data from a longitudinal study into the key management success factors in the fair trade industry provide insights into the essential nature of inter-organizational alliances and networks in creating the profitable and growing fair trade market in the UK. Drawing on three case studies and extensive industry interviews, we provide an interpretive perspective on the organizational relationships and business networks and the way in which these have engendered success for UK fair trade companies. Three types of benefit are derived from (...) the networks: competitive developments through virtual integration in which the organizations remain flexible and small while projecting size to the market; intellectual developments through the sharing of intellectual capital with a diverse network of organizations in many fields; and ideological developments through an ideological network of like-minded individuals by which the companies can prevent the co-opting of the original purpose of fair trade. However, relative success at leveraging these benefits is influenced by three managerial factors: partner choice, partner use and partner management. (shrink)

Fair Trade companies have pulled off an astonishing tour de force. Despite their relatively small size and lack of resources, they have managed to achieve considerable commercial success and, in so doing, have put the fair trade issue firmly onto industry agendas. We analyse the critical role played by social capital in this success and demonstrate the importance of values as an exploitable competitive asset. Our research raises some uncomfortable questions about whether fair trade has 'sold out' to the mainstream (...) and whether these companies have any independent future or whether their ultimate success lies in the impact they have had on day-to-day trading behaviour. (shrink)

We introduce a new logical operator CSTC and show that incorporating this operator into first-order logic enables as to capture the complexity class PSPACE. We also show that by varying how the operator is applied we can capture the complexity classes P, NP, the classes of the Polynomial Hierarchy PH, and PSPACE. As such, the operator CSTC can be regarded as a general purpose operator. We also give applications of these characterizations by showing that P and NP coincide with those (...) problems accepted by two new classes of program schemes , by producing some new complete problems for various complexity classes where the reductions are from first principles and do not use known complete problems , and by giving a simple proof that first-order logic incorporated with the least fixed point operator captures P. (shrink)

We investigate why similar extensions of first-order logic using operators corresponding to NP-complete decision problems apparently differ in expressibility: the logics capture either NP or LNP. It had been conjectured that the complexity class captured is NP if and only if the operator is monotone. We show that this conjecture is false. However, we provide evidence supporting a revised conjecture involving finite variations of monotone problems.

We investigate the definability in monadic ∑11 and monadic Π11 of the problems REGk, of whether there is a regular subgraph of degree k in some given graph, and XREGk, of whether, for a given rooted graph, there is a regular subgraph of degree k in which the root has degree k, and their restrictions to graphs in which every vertex has degree at most k, namely REGkk and XREGkk, respectively, for k ≥ 2 . Our motivation partly stems from (...) the fact that REGkk and XREGkk are logspace equivalent to CONN and REACH, respectively, for k ≥ 3, where CONN is the problem of whether a given graph is connected and REACH is the problem of whether a given graph has a path joining two given vertices. We use monadic first - order reductions, monadic ∑11 games and a recent technique due to Fagin, Stockmeyer and Vardi to almost completely classify whether these problems are definable in monadic ∑11 and monadic Π11, and we compare the definability of these problems. (shrink)

Though full of promise, Big Data research success is often contingent on access to the newest, most advanced, and often expensive hardware systems and the expertise needed to build and implement such systems. As a result, the accessibility of the growing number of Big Data-capable technology solutions has often been the preserve of business analytics. Pay as you store/process services like Amazon Web Services have opened up possibilities for smaller scale Big Data projects. There is high demand for this type (...) of research in the digital humanities and digital sociology, for example. However, scholars are increasingly finding themselves at a disadvantage as available data sets of interest continue to grow in size and complexity. Without a large amount of funding or the ability to form interdisciplinary partnerships, only a select few find themselves in the position to successfully engage Big Data. This article identifies several notable and popular Big Data technologies typically implemented using large and extremely powerful cloud-based systems and investigates the feasibility and utility of development of Big Data analytics systems implemented using low-cost commodity hardware in basic and easily maintainable configurations for use within academic social research. Through our investigation and experimental case study, we found that not only are solutions like Cloudera’s Hadoop feasible, but that they can also enable robust, deep, and fruitful research outcomes in a variety of use-case scenarios across the disciplines. (shrink)

Martin Heidegger is, perhaps, the most controversial philosopher of the twentieth-century. Little has been written on him or about his work and its significance for educational thought. This unique collection by a group of international scholars reexamines Heidegger's work and its legacy for educational thought.

In a series of recent articles, Robin Jeshion has developed a theory of singular thought which she calls ‘cognitivism’. According to Jeshion, cognitivism offers a middle path between acquaintance theories—which she takes to impose too strong a requirement on singular thought, and semantic instrumentalism—which she takes to impose too weak a requirement. In this article, I raise a series of concerns about Jeshion's theory, and suggest that the relevant data can be accommodated by a version of acquaintance theory that distinguishes (...) unsuccessful thoughts of singular form from successful singular thoughts, and in addition allows for ‘trace-based’ acquaintance. (shrink)

Jeffery et al. accurately identify the importance of developing an understanding of spatial reference frames in a three-dimensional world. We examine human spatial cognition via a unique paradigm that investigates the role of saliency and adjusting reference frames. This includes work with adults, typically developing children, and children who develop non-typically (e.g., those with autism).

A probabilistic theory of causation is a theory which holds that the central feature of causation is that causes raise the probability of their effects. In this dissertation, I defend Hans Reichenbach's original version of the probabilistic theory of causation, which analyses causal relations in terms of a three place statistical betweenness relation. Unlike most discussions of this theory, I hold that the statistical relation should be taken as a sufficient, but not as a necessary , condition for causal betweenness. (...) With this difference in interpretation, Reichenbach's theory is shown to be immune to all of the criticisms which have been raised against it in the last fifty years. ;Reichenbach's main purpose in defending a probabilistic theory of causation was to use it in giving an analysis of the direction of time. I defend this view, arguing that the arrow of causation is more basic than any of the other arrows of time---metaphysical, psychological or physical. In particular, I argue against the popular view that the direction of time is given by the physical fact that entropy only increases in one direction. I further show that the probabilistic theory of causation is particularly suited to the task of analysing the various arrows of time. In my final chapter, I also suggest that the probabilistic theory of causation may be fruitfully applied to the analysis of some important puzzles in the interpretation of quantum mechanics. (shrink)

Can we understand important social issues by studying individual personalities and decisions? Or are societies somehow more than the people in them? Sociologists have long believed that psychology can't explain what happens when people work together in complex modern societies. In contrast, most psychologists and economists believe that if we have an accurate theory of how individuals make choices and act on them, we can explain pretty much everything about social life. Social Emergence takes a new approach to these longstanding (...) questions. Sawyer argues that societies are complex dynamical systems, and that the best way to resolve these debates is by developing the concept of emergence, focusing on multiple levels of analysis - individuals, interactions, and groups - and with a dynamic focus on how social group phenomena emerge from communication processes among individual members. This book makes a unique contribution not only to complex systems research but also to social theory. (shrink)

In this article, I reconsider the question of how best to understand Sartre's concept of bad faith by investigating it through the Derridean lens of deconstruction. I argue that Sartre's discussion of bad faith in _Being and Nothingness_ mirrors Derrida's criticisms of structuralism in 'Structure, Sign, and Play in the Discourse of the Human Sciences'. Examining their distinctive discussions of 'play', I claim that Derrida's unique deconstructive interpretation of this notion operates within Sartre's criticisms of the 'spirit of seriousness'. I (...) reinterpret bad faith as the attempt to solidify a permanent structure of one's personality, in order to avoid or escape from the 'play' or 'freedom' built into structures and our existential condition, and conclude that embracing 'play' is an essential characteristic of authenticity. (shrink)

In this paper I clarify my argument for the claim that contrastive self-knowledge entails anti-individualism.

Canonical economic agents act so as to maximize a single, representative, utility function. However, there is accumulating evidence that heterogeneity in thought processes may be an important determinant of individual behavior. This paper investigates the implications of a vector-valued generalization of the Expected Utility paradigm, which permits agents either to deliberate as per Homo economics, or to act impulsively. This generalized decision theory is applied to explain the crowding-out effect, irrational educational investment decisions, persistent social inequalities, the pervasive influence of (...) non-cognitive ability on socio-economic outcomes, and the dynamic relationships between non-cognitive ability, cognitive ability, and behavioral biases. These results suggest that the generalized decision theory warrants further investigation. (shrink)

This is a defence of the claim that names are predicates with a demonstrative element in their singular use.

Juhani Yli-Vakkuri has argued that the Twin Earth thought experiments offered in favour of semantic externalism can be replaced by a straightforward deductive argument from premisses widely accepted by both internalists and externalists alike. The deductive argument depends, however, on premisses that, on standard formulations of internalism, cannot be satisfied by a single belief simultaneously. It does not therefore, constitute a proof of externalism. The aim of this article is to explain why.

In Questioning Technology, Feenberg accuses Heidegger of an untenable 'technological essentialism'. Feenberg's criticisms are addressed not to technological essentialism as such, but rather to three particular kinds of technological essentialism: ahistoricism, substantivism, and one-dimensionalism. After these three forms of technological essentialism are explicated and Feenberg's reasons for finding them objectionable explained, the question whether Heidegger in fact subscribes to any of them is investigated. The conclusions are, first, that Heidegger's technological essentialism is not at all ahistoricist, but the opposite, an (...) historical conception of the essence of technology which serves as the model for Feenberg's own view. Second, that while Heidegger does indeed advocate a substantivist technological essentialism, he offers a plausible, indirect response to Feenberg's voluntaristic, Marcusean objection. Third, that Heidegger's one-dimensional technological essentialism is of a non-objectionable variety, since it does not force Heidegger to reject technological devices in toto. These conclusions help vindicate Heidegger's ground-breaking ontological approach to the philosophy of technology. (shrink)

In Part I, the author argued for nonreductive individualism (NRI), an account of the individual-collective relation that is ontologically individualist yet rejects methodological individualism. However, because NRI is ontologically individualist, social entities and properties would seem to be only analytic constructs, and if so, they would seem to be epiphenomenal, since only real things can have causal power. In general, a nonreductionist account is a relatively weak defense of sociological explanation if it cannot provide an account of how social properties (...) can participate in causal relations. In this article, the author extends NRI to address this weakness and provides an account of social causation that he refers to as supervenient causation. Key Words: individualism • collectivism • social realism • social causation. (shrink)

Buddhism comes up several times in The Good Place. According to Buddhism, what we think of as a “self” or “soul” is merely a convenient designator, a useful fiction, that doesn't correspond to any actual thing in the world. In The Good Place, Eleanor's entire journey to becoming a better person is predicated on the belief that she can indeed change herself for the better. If change is possible, it is because that part of the self is capable of change. (...) Buddhist equanimity does not involve ignoring the suffering of others. In fact, compassion is one of the chief virtues of Buddhism. Over the course of The Good Place, the characters transform from self‐obsessed people who don't understand the amount of harm they are causing to themselves and others into people who have come to grips with the consequences of their past deeds. (shrink)

In this brief response to Joona Räsänen’s argument for the coherence and desirability of being able legally to change one’s age, I outline a couple of reasons for thinking that the case he makes is deeply flawed. As such, I contend that we have no reason to think that age should be the kind of thing that one should be able to change legally. Moreover, we have at least one good reason for thinking that legal age change would be positively (...) undesirable. (shrink)

Conceptual engineering is to be explained by appeal to the externalist distinction between concepts and conceptions. If concepts are determined by non-conceptual relations to objective properties rather than by associated conceptions (whether individual or communal), then topic preservation through semantic change will be possible. The requisite level of objectivity is guaranteed by the possibility of collective error and does not depend on a stronger level of objectivity, such as mind-independence or independence from linguistic or social practice more generally. This means (...) that the requisite level of objectivity is exhibited not only by natural kinds, but also by a wide range of philosophical kinds, social kinds and artefactual kinds. The alternative externalist accounts of conceptual engineering offered by Herman Cappelen and Derek Ball fall back into a kind of descriptivism which is antithetical to externalism and fails to recognise this basic level of objectivity. (shrink)

Words change meaning over time. Some meaning shift is accompanied by a corresponding change in subject matter; some meaning shift is not. In this paper I argue that an account of linguistic meaning can accommodate the first kind of case, but that a theory of concepts is required to accommodate the second. Where there is stability of subject matter through linguistic change, it is concepts that provide the stability. The stability provided by concepts allows for genuine disagreement and ameliorative change (...) in the context of conceptual engineering. (shrink)

This book is a timely intervention in the areas of philosophy, history, and literature. As an exploration of the modern political order and its racial genealogy, it emerges at a moment when scholars and activists alike are wrestling with how to understand subject formation from the perspective of the subordinated rather than from dominant social and philosophical modes of thought. For Sawyer, studying the formation of racialized subjects requires a new imagining of marginalized subjects. Black subjectivity is not viewed (...) from the static imaginings of social death, alienation, ongoing abjection, or as a confrontation with the treat of oblivion. Sawyer innovates the term "fractured temporality," conceptualizing Black subjects as moving within and across temporalities in transition, incorporated, yet excluded, marked with the social death of Atlantic slavery and the emergent political orders it etched, and still capable of exerting revolutionary force that acts upon, against, and through racial oppression. (shrink)

As a result of the COVID-19 global pandemic, paramedics in the UK face unprecedented challenges in the care of acutely unwell patients and their family members. This article will describe and discuss a new ethical dilemma faced by clinicians in the out-of-hospital environment during this time, namely the delivery of bad news to family members who are required to remain at home and self-isolate while the critically unwell patient is transported to hospital. I will discuss some failings of current practice (...) and reflect on some of the ethical and practical challenges confronting paramedics in these circumstances. I conclude by making three recommendations: first, that dedicated pastoral outreach teams ought to be set up during pandemics to assist family members of patients transported to hospital; second, I offer a framework for how bad news can be delivered during a lockdown in a less damaging way; and finally, that a new model of bad news delivery more suited for unplanned, time-pressured care should be developed. (shrink)

Heidegger, Art, and Postmodernity offers a radical new interpretation of Heidegger's later philosophy, developing his argument that art can help lead humanity beyond the nihilistic ontotheology of the modern age. Providing pathbreaking readings of Heidegger's 'The Origin of the Work of Art' and his notoriously difficult Contributions to Philosophy, this book explains precisely what postmodernity meant for Heidegger, the greatest philosophical critic of modernity, and what it could still mean for us today. Exploring these issues, Iain D. Thomson examines (...) several postmodern works of art, including music, literature, painting and even comic books, from a post-Heideggerian perspective. Clearly written and accessible, this book will help readers gain a deeper understanding of Heidegger and his relation to postmodern theory, popular culture and art. (shrink)

This is a contribution to the symposium on Herman Cappelen’s book Fixing Language. Cappelen proposes a metasemantic framework—the “Austerity Framework”—within which to understand the general phenomenon of conceptual engineering. The proposed framework is austere in the sense that it makes no reference to concepts. Conceptual engineering is then given a “worldly” construal according to which conceptual engineering is a process that operates on the world. I argue, contra Cappelen, that an adequate theory of conceptual engineering must make reference to concepts. (...) This is because concepts are required to account for topic continuity, a phenomenon which lies at the heart of projects in conceptual engineering. I argue that Cappelen’s own account of topic continuity is inadequate as a result of the austerity of his metasemantic framework, and that his worldly construal of conceptual engineering is untenable. (shrink)

This paper provides an externalist account of talk and thought that clearly distinguishes the two. It is argued that linguistic meanings and concepts track different phenomena and have different explanatory roles. The distinction, understood along the lines proposed, brings theoretical gains in a cluster of related areas. It provides an account of meaning change which accommodates the phenomenon of contested meanings and the possibility of substantive disagreement across theoretical divides, and it explains the nature and value of conceptual engineering in (...) a way that addresses recent prominent concerns. (shrink)

Claims that there are good arguments for a public health service that do not amount to arguments for a national health service, but for something that looks far more like a transnational health service.